Combined glyphosate and chlorpyrifos-based pesticides impair innate and adaptive immune functions: an in vitro approach
Environmentally relevant doses of glyphosate and chlorpyrifos-based pesticide mixtures disrupt innate and adaptive immune effector functions that are critical for the control of neoplastic cells and nascent tumor foci, suggesting that current risk assessments underestimate the immunotoxicity of combined formulations.
Authors
- Carolina I. Domaica (ORCID: https://orcid.org/0000-0001-9596-4889)
- Norberto W. Zwirner (ORCID: https://orcid.org/0000-0001-7098-359X)
- María Sofía Amarilla
- Mercedes B. Fuertes (ORCID: https://orcid.org/0000-0002-2734-1468)
- María Cecilia Santilli
- Mariana Gantov
- Adrián David Friedrich
- María Victoria Regge (ORCID: https://orcid.org/0000-0003-0702-530X)
- Daniela Belén Gareis
- María Eugenia Ordoñez
- María Natalia Rubinsztain
- María Eugenia Gaillardou
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
- Fundación Ciencias Exactas y Naturales (AR)
- Experimental Medicine and Biology Institute (AR)
Publication Details
- Journal
- Environmental Health
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12940-025-01241-z
- Primary Topic
- Pesticide and Herbicide Environmental Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Williams
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Fundación René Barón
- Agencia Nacional de Promoción Científica y Tecnológica