Study of effect of Muco Adhesive Polymers on Domperidone Hard Candy Lozenges

Objective: The main object of the work is to formulate and evaluate hard lozenges of Domperidone using different mucoadhesive polymers. Methods: The solubility of Domperidone was enhanced by co crystallization technique. The cocrystals were prepared with different coformers (PABA, Succinic acid, Salicylic acid) at different weight ratios (1:1, 1:3) by solvent evaporation method. With these conformers hard lozenges were prepared by hot congealing technique. The 6 formulations were prepared and F1 to F3 formulations were prepared with tamarind kernel powder as muco adhesive polymer and F4, F5 and F6 were prepared with sodium carboxy methyl cellulose. Microbial attack test was performed for all the formulations by streak plate method and cylinder method. All the formulation s evaluated for various parameters like weightvariation, hardness, thickness, disintegration, mouth dissolving time and dissolution. Mucoadhesive strength was measured using modified physical balance method. Results: The results for solubility enhancement ratio has shown that increase in the concentration of coformer increases the aqueous solubility of Domperidone and PABA (1:3) has shown 50 folds increase in solubility. The formulations without preservative have shown microbial growth hence in F4toF6 methyl paraben was added as preservative. All the evaluation parameters with in the acceptance limits and the formulation with PABA at 1:3 ratio has shown 93.6 % drug release within 30minutes. Conclusion: The research has concluded that the solubility of Domperidone increased more with Para amino benzoic acid with cocrystallization technique. Mucoadhesive studies has concluded that tamarind kernel powder has high muco adhesive strength and hence it can be used as mucoadhesive polymer in various formulations.