Identification and validation of cuproptosis-related immune checkpoint expression for glioblastoma
The expression levels of immune checkpoint genes CD276, CD40, and TNFSF14 related to copper death are positively correlated with the prognosis of GBM patients, while the expression level of TNFSF9 is negatively correlated with the prognosis of GBM patients. This study establishes a novel link between immune checkpoint genes and cuproptosis, bridging copper-induced cell death mechanisms with immunotherapy for glioma.
Authors
- Jianping Zeng (ORCID: https://orcid.org/0000-0002-4485-6164)
- Rajneesh Mungur
- Bin Tang (ORCID: https://orcid.org/0000-0001-6096-0837)
- Jinhui Huang
- Jiugeng Feng (ORCID: https://orcid.org/0000-0002-8249-6120)
- Shushan Hua
- Shuai Liu (ORCID: https://orcid.org/0000-0002-1519-6400)
- Mingjie Zhang (ORCID: https://orcid.org/0000-0001-9404-0190)
- Jing Liu (ORCID: https://orcid.org/0000-0003-4690-1886)
- Shoufang Tong
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Hangzhou Medical College (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12885-025-15195-5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Jiangxi Province
- Nanchang University
- Education Department of Jiangxi Province