Trichomonas vaginalis adhesion protein 65 facilitates human papillomavirus entry via SPCS1-mediated upregulation of CD151 and HSPG2 in keratinocyte lineage
Our study unveils a previously uncharacterized mechanism by which T. vaginalis exacerbates HPV infection: TvAP65 hijacks SPCS1 to transcriptionally upregulate CD151 and HSPG2, thereby facilitating HPV entry into host cells. This TvAP65-SPCS1-CD151/HSPG2 axis highlights potential therapeutic targets to disrupt the synergy between HPV and T. vaginalis, offering new strategies for cervical cancer prevention.
Authors
- Wanxing Sheng (ORCID: https://orcid.org/0000-0002-1908-2902)
- Zhenke Yang (ORCID: https://orcid.org/0000-0001-8693-9462)
- Zhenchao Zhang (ORCID: https://orcid.org/0000-0002-2405-2038)
- Xuefang Mei (ORCID: https://orcid.org/0000-0002-0159-1119)
- Shuai Wang (ORCID: https://orcid.org/0000-0003-1636-5525)
- Wenjie Tian (ORCID: https://orcid.org/0009-0009-0174-7310)
- Xiaowei Tian
- Yani Zhang (ORCID: https://orcid.org/0000-0002-4028-5448)
Institutions
- Henan Medical University (CN)
Publication Details
- Journal
- Infectious Diseases of Poverty
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s40249-025-01381-x
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00