A Feasibility Study of Co-Established Patient-Derived Subcutaneous Xenograft and Organotypic Slice Cultures in Hormone-Naive Primary Prostate Cancer Preclinical Modeling: A Single-Institution Experience
Our findings establish both first-generation PDXs and PD-OSCs as valuable "avatar" models for translational research. However, PD-OSCs represent a more efficient and rapid platform for studying primary hormone-naïve PCa biology and evaluating treatment responses, holding significant promise as a predictive tool to guide personalized medicine.
Authors
- Antonella Farsetti (ORCID: https://orcid.org/0000-0002-8603-7925)
- Simona Nanni (ORCID: https://orcid.org/0000-0002-3320-1584)
- Dante Rotili (ORCID: https://orcid.org/0000-0002-8428-8763)
- M Bracco (ORCID: https://orcid.org/0000-0003-4757-3730)
- Claudio Grassi (ORCID: https://orcid.org/0000-0001-7253-1685)
- Luca Cis
- Cristian Ripoli (ORCID: https://orcid.org/0000-0002-5315-0163)
- Sara De Martino (ORCID: https://orcid.org/0000-0002-6226-4090)
- Carlo Gaetano (ORCID: https://orcid.org/0000-0002-5238-1832)
- Alfredo Pontecorvi (ORCID: https://orcid.org/0000-0003-0570-6865)
- Aurora Aiello (ORCID: https://orcid.org/0000-0002-8303-1528)
- Francesco Pinto (ORCID: https://orcid.org/0000-0003-1937-9957)
- Valeria Pecci (ORCID: https://orcid.org/0000-0001-9170-3593)
- Francesco Pierconti (ORCID: https://orcid.org/0000-0003-0951-4131)
- M Borsa (ORCID: https://orcid.org/0009-0005-8722-4350)
- Domenico Varacalli
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Roma Tre University (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Istituto Nazionale Biostrutture e Biosistemi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
Publication Details
- Journal
- Life
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3390/life15111719
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Università Cattolica del Sacro Cuore