Exploring Sex-Related Difference in Cerebrospinal Fluid/Blood Quotient of Albumin in Older Patients Undergoing Hip Fracture Surgery: Insight From the ORTODEL and BIODEL Study
Despite sample size and sex imbalance, our analyses highlight a sex-related discrepancy in BCSFB function in older patients underscoring the need for sex-specific QAlb reference ranges. Normalization of QAlb values by sex may be essential to prevent over- or underestimation of BCSFB dysfunction in the 2 sexes. Future studies with larger, balanced cohorts may clarify these differences.
Authors
- Stefano Volpato (ORCID: https://orcid.org/0000-0003-4335-6034)
- Massimiliano Castellazzi (ORCID: https://orcid.org/0000-0001-6555-6075)
- Giuseppe Bellelli (ORCID: https://orcid.org/0000-0001-5430-0947)
- Lucía Lozano-Vicario (ORCID: https://orcid.org/0000-0003-2326-6891)
- Chukwuma Okoye (ORCID: https://orcid.org/0000-0003-2969-7393)
- María Cristina Ferrara (ORCID: https://orcid.org/0000-0002-7971-5943)
- Alice Margherita Ornago (ORCID: https://orcid.org/0009-0008-7927-793X)
- Nicolás Martínez‐Velilla (ORCID: https://orcid.org/0000-0001-9576-9960)
- Beatrice Arosio (ORCID: https://orcid.org/0000-0002-0615-3580)
- Elena Pinardi (ORCID: https://orcid.org/0009-0004-8068-9406)
Institutions
- Universidad Pública de Navarra (UPNA) (ES)
- University of Milan (IT)
- University of Ferrara (IT)
- Instituto de Salud Carlos III (ES)
- Azienda Ospedaliera San Gerardo (IT)
- Navarre Institute of Health Research (ES)
- Navarrabiomed (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- University of Milano-Bicocca (IT)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Biomarker Insights
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/11772719251385928
- Citations
- 1
- Primary Topic
- Hip and Femur Fractures
- Type
- article
- Field-Weighted Citation Impact
- 2.01