Efficacy of Needle and Microneedle Mesotherapy in Reducing Signs of Skin Aging—A Split-Face Comparative Study

Introduction: Major manifestations of facial skin aging include the loss of firmness and elasticity, the appearance of wrinkles, and various pigmentary changes. Mesotherapy—both needle and microneedle-based—is a commonly chosen procedure that effectively revitalizes and stimulates the skin. The aim of this study was to compare the effectiveness of both techniques in reducing the signs of skin aging using a product containing fragmented hyaluronic acid and an amino acid complex. Materials and Methods: The study included 20 female participants aged 35–60 years who underwent a series of four treatment sessions in a split-face design. One side of the face was treated with needle mesotherapy, while the other side received microneedle mesotherapy. In each session, 5 mL of a preparation containing fragmented hyaluronic acid, glutathione, stabilized vitamin C, and an amino acid complex was administered. Skin parameters (hydration, pH, sebum level, erythema, and pigmentation), photographic documentation, participants’ subjective evaluations, and pain scores were assessed. Results: Both techniques led to significant improvements in skin condition. Microneedle mesotherapy was more effective in enhancing hydration, regulating sebum and pH, and was better tolerated in terms of pain. Needle mesotherapy demonstrated greater efficacy in reducing pigmentation. Patient satisfaction was high in both groups. Conclusions: Both needle and microneedle mesotherapy are effective treatments for aging skin, although their mechanisms of action differ. The choice of technique should be tailored to the individual needs of the skin and the expectations of the patient.