Inhibition of interleukin-1 receptor-associated kinase (IRAK)-4 provides partial rescue of interleukin-1 beta induced functional and gene expression changes in equine tenocytes
Together, this data demonstrates that IL-1β has a broad mechanism of action on tendon cells which cannot be fully mediated by targeting specific parts of the signalling pathway.
Authors
- Deborah J. Guest (ORCID: https://orcid.org/0000-0002-0034-3332)
- Ross E. Beaumont (ORCID: https://orcid.org/0000-0002-2267-073X)
- Caroline Flood
Institutions
- Royal Veterinary College (GB)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1007/s11033-025-11219-2
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Petplan Charitable Trust