TNF-α signaling drives myeloid skewing and clonal expansion of stem and progenitors in <i>RUNX1</i>-familial platelet disorder

Authors

Aishwarya Sahasrabudhe (ORCID: https://orcid.org/0000-0002-8793-8135)
Kathryn Schabel (ORCID: https://orcid.org/0000-0003-4138-2650)
Luiza H. Ostrowski
John McClatchy
Anupriya Agarwal (ORCID: https://orcid.org/0000-0002-8319-6162)
Erica Bresciani
Ryland Kagan (ORCID: https://orcid.org/0000-0002-4892-5753)
Mona Mohammadhosseini (ORCID: https://orcid.org/0000-0002-5643-6052)
Paul Liu (ORCID: https://orcid.org/0000-0002-6779-025X)
Rebekah J. Knight

Institutions

Oregon Health & Science University (US)
National Human Genome Research Institute (US)

Publication Details

Journal: Haematologica
Published: 2025-11-06
DOI: https://doi.org/10.3324/haematol.2025.288410
Primary Topic: Platelet Disorders and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Cancer Research Institute
Oregon Health and Science University
Edward P. Evans Foundation
National Heart, Lung, and Blood Institute
National Human Genome Research Institute
National Cancer Institute

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article

TNF-α signaling drives myeloid skewing and clonal expansion of stem and progenitors in RUNX1-familial platelet disorder

Aishwarya Sahasrabudhe, Kathryn Schabel, Luiza H. Ostrowski, John McClatchy et al.

Nov 6, 2025

Haematologica

Platelet Disorders and Treatments

article

TNF-α signaling drives myeloid skewing and clonal expansion of stem and progenitors in RUNX1-familial platelet disorder

Aishwarya Sahasrabudhe, Kathryn Schabel, Luiza H. Ostrowski, John McClatchy, Anupriya Agarwal, Erica Bresciani, Ryland Kagan, Mona Mohammadhosseini, Paul Liu, Rebekah J. Knight

November 6, 2025article en

Abstract

No abstract available for this paper.

Haematologica

Oregon Health & Science University (US), National Human Genome Research Institute (US)

Cancer Research Institute, Oregon Health and Science University, Edward P. Evans Foundation, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute

Openalex Percentile: Top 57%

Platelet Disorders and Treatments

DOI Open Access PDF OpenAlex

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