Na <sub>2</sub> S-catalyzed dehydrogenative condensation of 2-aminobenzyl alcohols and ketones: a synthesis of quinolines
We report sodium sulfide as a simple, inexpensive, yet powerful and sustainable catalyst for synthesizing quinolines and 1,8-naphthyridines. This new method involves the dehydrogenative condensation of 2-aminobenzyl alcohols with ketones and proceeds under mild heating conditions. It also demonstrates a broad substrate scope, achieving the transformation without the need for transition metals, chiral ligands, additives, or even solvents.
Authors
- Thanh Bình Nguyễn (ORCID: https://orcid.org/0000-0001-8779-9641)
- Duc Long Le (ORCID: https://orcid.org/0000-0003-4714-2279)
- Quoc Anh Ngo (ORCID: https://orcid.org/0000-0002-2319-2880)
- Thi Thanh Tam Nguyen (ORCID: https://orcid.org/0000-0003-2463-3040)
- Le Anh Nguyen
Institutions
- Université Paris-Sud (FR)
- Centre National de la Recherche Scientifique (FR)
- Institut de Chimie des Substances Naturelles (FR)
- Université Paris-Est Créteil (FR)
- Université Paris-Saclay (FR)
- Institut de Chimie et des Matériaux Paris-Est (FR)
- Vietnam Academy of Science and Technology (VN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01438g
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00