Opportunistic AI-derived adiposity measures from coronary artery calcium scans predict new-onset type 2 diabetes in adults without obesity or hyperglycemia: insights from the AI-CVD study within MESA
AI-derived adiposity measures from CAC scans-especially liver fat-can identify adults without obesity or hyperglycemia at elevated risk for developing T2DM. These findings underscore the potential of AI-enabled opportunistic screening during CAC imaging to support early T2DM risk stratification in individuals not captured by current clinical guidelines.
Authors
- Prediman K. Shah (ORCID: https://orcid.org/0000-0002-6351-8291)
- Claudia I. Henschke (ORCID: https://orcid.org/0000-0002-6085-5305)
- Andrea D. Branch (ORCID: https://orcid.org/0000-0003-2865-3188)
- Rozemarijn Vliegenthart (ORCID: https://orcid.org/0000-0002-7262-3376)
- Robert A. Kloner (ORCID: https://orcid.org/0000-0002-6258-0544)
- Amir Vahedian‐Azimi (ORCID: https://orcid.org/0000-0002-1678-7608)
- Ali Hashemi (ORCID: https://orcid.org/0000-0002-7258-5541)
- MohammadHossein MozafaryBazargany (ORCID: https://orcid.org/0000-0001-9897-6172)
- Jagat Narula
- David J. Maron (ORCID: https://orcid.org/0000-0002-4867-8588)
- Anthony P. Reeves (ORCID: https://orcid.org/0000-0002-1451-3080)
- Michael V. McConnell (ORCID: https://orcid.org/0000-0001-8743-0932)
- Emelia J. Benjamin (ORCID: https://orcid.org/0000-0003-4076-2336)
- Khurram Nasir (ORCID: https://orcid.org/0000-0001-5376-2269)
- Matthew Jay Budoff (ORCID: https://orcid.org/0000-0002-9616-1946)
- Susan K. Fried (ORCID: https://orcid.org/0000-0003-1101-9332)
- Jakob Wasserthal (ORCID: https://orcid.org/0000-0002-9921-5698)
- Nathan D. Wong (ORCID: https://orcid.org/0000-0003-1102-7324)
- Zahi Adel Fayad (ORCID: https://orcid.org/0000-0002-3439-7347)
- Thomas Atlas
- Kyle Atlas
- Seyed Reza Mirjalili (ORCID: https://orcid.org/0000-0002-3456-5128)
- Morteza Naghavi
- Daniel A. Levy (ORCID: https://orcid.org/0000-0003-3086-4355)
- Jeffrey I. Mechanick
- David F. Yankelevitz
- Kim A. Williams
- Chen‐Yu Zhang (ORCID: https://orcid.org/0000-0002-7329-7162)
Institutions
- Boston University (US)
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- Boston Medical Center (US)
- Huntington Medical Research Institutes (US)
- Houston Methodist (US)
- University Medical Center Groningen (NL)
- University of Louisville (US)
- University of California, Irvine (US)
- Cornell University (US)
- University Hospital of Basel (CH)
- Orange County Research Center (US)
- Hospital Base (CL)
- Mount Sinai Hospital (US)
- Angeles Clinic and Research Institute (US)
- National Heart, Lung, and Blood Institute (US)
- Methodist Hospital (US)
- Stanford Medicine (US)
- The University of Texas Health Science Center (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s13098-025-01970-8
- Citations
- 2
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences