Role of PRKCZ non-synonymous genetic variants in breast cancer development
All five nsSNPs exhibited potential as predictive and prognostic biomarkers for BC. However, the current study findings should be validated by conducting research on large cohorts with representation from diverse population. Furthermore, biological mechanism by which these nsSNPs cause BC pathogenesis could be explored in future studies.
Authors
- Yasmin Badshah
- Khushbukhat Khan (ORCID: https://orcid.org/0000-0002-9946-9057)
- Janeen H. Trembley (ORCID: https://orcid.org/0000-0003-3597-2611)
- Muhammad Armaghan
- Ali Almajwal (ORCID: https://orcid.org/0000-0002-9798-7117)
- Lubna Meraj (ORCID: https://orcid.org/0000-0001-6669-6571)
- Suhail Razak (ORCID: https://orcid.org/0000-0003-2167-8630)
- Maria Shabbir (ORCID: https://orcid.org/0000-0002-5685-3059)
- Aneela Mustafa
- Tayyaba Afsar (ORCID: https://orcid.org/0000-0003-3181-5731)
Institutions
- University of Minnesota (US)
- Rawalpindi Medical University (PK)
- King Saud Medical City (SA)
- King Saud University (SA)
- Minneapolis VA Health Care System (US)
- University of Minnesota Medical Center (US)
- National University of Sciences and Technology (PK)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12935-025-04045-w
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Saud University