Aniline-induced refractory methemoglobinemia in polytrauma: successful management with erythrocytapheresis
Aniline exposure leads to the oxidation of ferrous iron (Fe2 +) in hemoglobin to ferric iron (Fe3 +), resulting in methemoglobinemia and impaired oxygen delivery. While methylene blue remains the first-line treatment, erythrocytapheresis proved effective in restoring tissue oxygenation in refractory methemoglobinemia complicated by hemorrhagic and traumatic shock.
Authors
- Šárka Blahutová (ORCID: https://orcid.org/0000-0001-7598-8891)
- Marcela Káňová (ORCID: https://orcid.org/0000-0001-8880-8925)
- Paula Dzurňáková
- Karolína Lečbychová
- Denis Buršík
- Tereza Romanová
Institutions
- University of Ostrava (CZ)
- Masaryk University (CZ)
- University Hospital Ostrava (CZ)
- Czech Academy of Sciences, Institute of Physiology (CZ)
Publication Details
- Journal
- International Journal of Emergency Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12245-025-01026-8
- Citations
- 1
- Primary Topic
- Methemoglobinemia and Tumor Lysis Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 1.52