Does ginsenoside Rg1 promote intervertebral disc repair? An experimental study insights into ferroptosis mechanism
Ginsenoside Rg1 can mitigate IVDD by inhibiting ferroptosis in NP cells. The NRF2/GPX4 pathway was validated as the key ferroptosis pathway through which ginsenoside Rg1 exerts its therapeutic effects on IVDD.
Authors
- Fuyong Wang (ORCID: https://orcid.org/0000-0003-1202-5283)
- Zhengfeng Lu (ORCID: https://orcid.org/0000-0001-9644-6039)
- Qing Yang (ORCID: https://orcid.org/0000-0002-5068-6085)
- Feiyun Xia (ORCID: https://orcid.org/0009-0000-9173-8913)
- Dongliang Gong
- Xiaoxia Tong (ORCID: https://orcid.org/0000-0001-8989-8643)
- Nong Chen
- Baihan Sun
- Kelv Shen
Institutions
- Fudan University (CN)
- Soochow University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Zhongshan Hospital (CN)
- Yueyang Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12967-025-07047-4
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00