Anabolic Effects of Salbutamol Are Lost Upon Immobilization
Salbutamol increases muscle mass and glucose uptake, although these effects are limited to active but not inactive muscles. This demonstrates that the mechanism of action and efficacy of β2-adrenoreceptor signalling are hampered upon immobilization, which offers potential for a combined treatment intervention of reintroducing muscle contraction and salbutamol administration to improve muscle mass and clinical outcomes during episodes of physical inactivity.
Authors
- Doaa R. Abdelrahman (ORCID: https://orcid.org/0000-0001-9847-5714)
- Benjamin T. Wall (ORCID: https://orcid.org/0000-0002-6019-6709)
- Marlou L. Dirks (ORCID: https://orcid.org/0000-0002-9189-1042)
- Mandy V. Dunlop
- Andrew J. Murton (ORCID: https://orcid.org/0000-0002-9474-9113)
- Esther van Duijn (ORCID: https://orcid.org/0009-0000-9704-4277)
- Bruno Guigas (ORCID: https://orcid.org/0000-0002-8856-5799)
- Martien P. M. Caspers (ORCID: https://orcid.org/0000-0002-0248-4008)
- Jaap Keijer (ORCID: https://orcid.org/0000-0002-9720-7491)
- Nanda Keijzer
- Lars Verschuren (ORCID: https://orcid.org/0000-0002-7847-9037)
- Francis B. Stephens (ORCID: https://orcid.org/0000-0001-6312-5351)
- Anita van Nieuwkoop
- Tom S. O. Jameson
- Arie G. Nieuwenhuizen (ORCID: https://orcid.org/0000-0003-0999-5422)
- Nicole Worms
- Anita M. van den Hoek (ORCID: https://orcid.org/0000-0002-7077-8446)
- Jelle C. B. C. de Jong (ORCID: https://orcid.org/0000-0002-5154-4900)
- Robert Andrews (ORCID: https://orcid.org/0000-0003-4939-1738)
- Wouter H. J. Vaes
Institutions
- Netherlands Organisation for Applied Scientific Research (NL)
- University of Exeter (GB)
- Leiden University Medical Center (NL)
- NIHR Exeter Clinical Research Facility (GB)
- The University of Texas Medical Branch at Galveston (US)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1002/jcsm.70114
- Primary Topic
- Pharmacological Effects and Assays
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health~Holland