Metabolic reprogramming through PIM3 inhibition reverses hypoxia-induced CAR-T cell dysfunction in solid tumors
This work identifies PIM3 as a previously underexplored target that links hypoxia to CAR-T cell dysfunction and demonstrates that PIM3 inhibition can reverse these effects. These findings provide a mechanistic rationale for incorporating PIM3 inhibition into CAR-T cell manufacturing or engineering to improve their therapeutic potential in hypoxic solid tumors.
Authors
- Muya Zhou (ORCID: https://orcid.org/0000-0002-2219-071X)
- M.-H. Wang
- Luxia Xu (ORCID: https://orcid.org/0009-0003-5846-5724)
- Wenwen Chen (ORCID: https://orcid.org/0000-0002-5958-2696)
- Jinhua Hu (ORCID: https://orcid.org/0000-0002-0647-9898)
- Jia-Fei Hong
- Zhigang Guo
Institutions
- Nanjing Normal University (CN)
- Nanjing Institute of Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12967-025-07278-5
- Citations
- 2
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Nanjing Normal University
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Nanjing University
- Priority Academic Program Development of Jiangsu Higher Education Institutions