CDK1 may promote breast cancer progression through AKT activation and immune modulation

CDK1 acts as a multifaceted oncogenic factor in breast cancer, contributing to tumor growth and immune modulation. Its overexpression is linked to poor prognosis and enhanced immune infiltration, underscoring its potential as a diagnostic and therapeutic target. Targeting CDK1 or its downstream signaling pathways may offer novel strategies, particularly for aggressive subtypes such as Basal-like or triple-negative breast cancer.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-11-06
DOI
https://doi.org/10.3389/fonc.2025.1591706
Primary Topic
Cancer-related Molecular Pathways
Type
article
Field-Weighted Citation Impact
0.00
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article

CDK1 may promote breast cancer progression through AKT activation and immune modulation

Minxue Zhuang, Ruo Wang, Huanhong Zeng, Feili Cai et al.
Frontiers in Oncology
Cancer-related Molecular Pathways
article

CDK1 may promote breast cancer progression through AKT activation and immune modulation

Minxue Zhuang, Ruo Wang, Huanhong Zeng, Feili Cai, Hui Zhang, Ruijuan Wang, Mengbo Lin, Bochuan Liang
article en

Abstract

CDK1 acts as a multifaceted oncogenic factor in breast cancer, contributing to tumor growth and immune modulation. Its overexpression is linked to poor prognosis and enhanced immune infiltration, underscoring its potential as a diagnostic and therapeutic target. Targeting CDK1 or its downstream signaling pathways may offer novel strategies, particularly for aggressive subtypes such as Basal-like or triple-negative breast cancer.

Frontiers in OncologyVol. 15
Fujian Medical University (CN), Nanchang University (CN), Fujian Provincial Hospital (CN)
Openalex Percentile: Top 55%
Cancer-related Molecular Pathways
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CDK1 may promote breast cancer progression through AKT activation and immune modulation — Minxue Zhuang, Ruo Wang, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS