Photoactivated quercetin as an inhibitor of Porphyromonas gingivalis virulence factor Kgp and biofilms: Validation through in vitro assays, molecular docking, and ADMET profiling

Quercetin-based PDT effectively inhibits P. gingivalis biofilms and downregulates a key virulence gene. Due to its natural origin, safety, and effectiveness, it holds promise as a targeted and biocompatible treatment option for managing periodontal disease. Further in vivo investigations are needed to confirm these findings.

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Publication Details

Journal
Photodiagnosis and Photodynamic Therapy
Published
2025-11-06
DOI
https://doi.org/10.1016/j.pdpdt.2025.105272
Primary Topic
Oral microbiology and periodontitis research
Type
article
Field-Weighted Citation Impact
0.00
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article

Photoactivated quercetin as an inhibitor of Porphyromonas gingivalis virulence factor Kgp and biofilms: Validation through in vitro assays, molecular docking, and ADMET profiling

Maryam Pourhajibagher, Bahman Rahimi Esboei, Abbas Bahador, Ehsan Moghaddam et al.
Photodiagnosis and Photodynamic Therapy
Oral microbiology and periodontitis research
article

Photoactivated quercetin as an inhibitor of Porphyromonas gingivalis virulence factor Kgp and biofilms: Validation through in vitro assays, molecular docking, and ADMET profiling

Maryam Pourhajibagher, Bahman Rahimi Esboei, Abbas Bahador, Ehsan Moghaddam, Mohammadreza Moeininejad
article en

Abstract

Quercetin-based PDT effectively inhibits P. gingivalis biofilms and downregulates a key virulence gene. Due to its natural origin, safety, and effectiveness, it holds promise as a targeted and biocompatible treatment option for managing periodontal disease. Further in vivo investigations are needed to confirm these findings.

Photodiagnosis and Photodynamic TherapyVol. 57
Shahrekord University (IR), Tehran University of Medical Sciences (IR), Mazandaran University of Medical Sciences (IR)
Openalex Percentile: Top 62%
Oral microbiology and periodontitis research
DOIOpen Access PDFOpenAlex
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Photoactivated quercetin as an inhibitor of Porphyromonas gingivalis virulence factor Kgp and biofilms: Validation through in vitro assays, molecular docking, and ADMET profiling — Maryam Pourhajibagher, Bahman Rahimi Esboei, et al. · Photodiagnosis and Photodynamic Therapy (2025) | TGRS Research Map | TGRS