Connecting Visual Perception With Proton Therapy-Induced Optic Damage Using Archetypal Analysis
This is the first application of archetypal analysis for predicting radiation-induced optic neuropathy. It enables spatially grounded reconnection between patient perception and radiation damage along optic pathways. This approach offers new mechanistic insights into optic pathway injury towards voxel-level correlation between radiation dose and functional loss and supports data-driven personalization of radiotherapy.
Authors
- Cyril Moignier
- Thao-Nguyen Pham (ORCID: https://orcid.org/0009-0003-9342-6464)
- Nathan Azemar
- J.C. Quintyn (ORCID: https://orcid.org/0000-0001-9811-381X)
- Juliette Thariat (ORCID: https://orcid.org/0000-0003-4755-496X)
- Thibaud Mathis
- Mathieu Seraphim
Institutions
- Hôpital de la Croix-Rousse (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire de Physique Corpusculaire de Caen (FR)
- Centre François Baclesse (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- International Journal of Particle Therapy
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.ijpt.2025.101211
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00