Dynamic contrast-enhanced MRI reveals glymphatic dysfunction in mice with depressive-like behavior
CUMS-induced depressive-like behavior is linked to glymphatic dysfunction, characterized by impaired CSF influx/efflux and AQP4/astrocyte downregulation. DCE-MRI clustering analysis provides novel insights into spatiotemporal glymphatic abnormalities, highlighting potential therapeutic targets for depression.
Authors
- Jaimmie Que
- Qianqian Guan (ORCID: https://orcid.org/0009-0004-1809-0216)
- Cui Lyu
- Bo Gao (ORCID: https://orcid.org/0000-0001-6161-1903)
- Yiming Wang (ORCID: https://orcid.org/0000-0003-0513-9039)
- Fang Han (ORCID: https://orcid.org/0000-0003-3493-7304)
- Li Yang (ORCID: https://orcid.org/0000-0001-7448-8588)
- Yong Xia (ORCID: https://orcid.org/0000-0001-8454-087X)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.nbd.2025.107169
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 1.82