Integrated single-cell, spatial, and bulk transcriptomics reveal a chromatin regulator-TME prognostic framework guiding precision therapy in cervical cancer
This study develops a novel CRG-TME classifier to predict prognosis and therapy response in cervical cancer and unveils the inhibitory effect and underlying mechanism of TSPYL2 on cervical cancer progression.
Authors
- Jiaqian Bao
- Hanxi Zhou (ORCID: https://orcid.org/0009-0006-6737-2169)
- Xiong Tian (ORCID: https://orcid.org/0000-0002-8354-8447)
- He Qu
- Yixiao Pan
- Jianbo Liu (ORCID: https://orcid.org/0000-0001-8282-4078)
- Na Wang (ORCID: https://orcid.org/0000-0002-5806-4379)
- Rong Lin (ORCID: https://orcid.org/0009-0002-8075-2669)
- Dali Hu
Institutions
- Wenzhou Medical University (CN)
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Zhejiang Taizhou Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12967-025-07085-y
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00