ACT001 alleviates MASLD through gut microbiota–bile acid–FXR axis in mice
ACT001 exerted a multifactorial therapeutic effect on MASLD, potentially linked to the regulation of the gut microbiota-BAs-FXR axis. Thus, it has the potential to be an effective treatment for MASLD.
Authors
- Yuqiang Mi (ORCID: https://orcid.org/0000-0001-9930-6429)
- Bin Niu (ORCID: https://orcid.org/0000-0002-5190-3563)
- Hui Zhou (ORCID: https://orcid.org/0000-0001-8668-3743)
- Weike Chu (ORCID: https://orcid.org/0000-0002-4568-937X)
- Yonggang Liu (ORCID: https://orcid.org/0000-0002-8486-6332)
- Ping Li (ORCID: https://orcid.org/0000-0002-4492-4825)
- Ze Chen (ORCID: https://orcid.org/0000-0002-1780-4764)
- Xue Wu
- Yibing Zhou
- Jing Liu (ORCID: https://orcid.org/0009-0002-7077-4784)
Institutions
- Tianjin Infectious Diseases Hospital (CN)
- Tianjin People's Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Xian Yang Central Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1080/07853890.2025.2580773
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61