A Cost Consequence Analysis of Seven Diagnostic Strategies for Ovarian Cancer: A Model‐Based Economic Evaluation
At 12 months, no single diagnostic strategy was superior. Early diagnosis requires balancing cancer mortality, diagnostic yield, and cost. The IOTA ADNEX two-step strategy at a 10% threshold provided the best trade-off across these factors and is recommended for practice.
Authors
- Eleanor Williams (ORCID: https://orcid.org/0000-0003-4641-2409)
- Jonathan J Deeks (ORCID: https://orcid.org/0000-0002-8850-1971)
- Tom Roberts (ORCID: https://orcid.org/0000-0003-4991-974X)
- S. Perry (ORCID: https://orcid.org/0000-0002-6098-4369)
- Sudha Sundar (ORCID: https://orcid.org/0000-0002-5843-3015)
- Ridhi Agarwal (ORCID: https://orcid.org/0000-0002-6930-5617)
- Katie Scandrett (ORCID: https://orcid.org/0000-0001-6111-2805)
- Donal Griffin (ORCID: https://orcid.org/0009-0000-7974-7155)
- Fong Lien Kwong (ORCID: https://orcid.org/0000-0002-6245-2358)
- Mark Monahan (ORCID: https://orcid.org/0000-0002-1175-9421)
- Sarah Williams (ORCID: https://orcid.org/0000-0002-0779-6342)
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Cancer Research UK Clinical Trials Unit (GB)
- NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- BJOG An International Journal of Obstetrics & Gynaecology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1111/1471-0528.70074
- Citations
- 2
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Health Technology Assessment Programme