Preclinical development of [18F]TAAR1-2203 as a PET radioligand for imaging TAAR1 expression and receptor occupancy
[<sup>18</sup>F]TAAR1-2203 represents the first PET radioligand for TAAR1 imaging with favorable in vitro and in vivo performance characteristics, enabling non-invasive assessment of receptor expression and drug occupancy in peripheral TAAR1-expressing tissues. [<sup>18</sup>F]TAAR1-2203 holds promise for translational application in various drug development programs.
Authors
- Zhiwei Xiao (ORCID: https://orcid.org/0000-0001-5522-2813)
- Stefanie K. Pfister (ORCID: https://orcid.org/0000-0002-1394-3716)
- Luca B. Gobbi (ORCID: https://orcid.org/0000-0002-0563-2491)
- Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
- Linjing Mu (ORCID: https://orcid.org/0000-0001-5354-1546)
- Axel Paehler
- Chunyu Zhao (ORCID: https://orcid.org/0000-0003-0168-2130)
- A. Haider (ORCID: https://orcid.org/0009-0005-3704-0908)
- Roger D. Norcross
- Marius C. Hoener (ORCID: https://orcid.org/0000-0001-6510-6250)
- Xin Zhou (ORCID: https://orcid.org/0000-0002-7444-462X)
- Roger Schibli (ORCID: https://orcid.org/0000-0002-1537-3833)
- Yinlong Li (ORCID: https://orcid.org/0000-0002-8864-1712)
- Jiahui Chen (ORCID: https://orcid.org/0000-0001-9186-1110)
- Jian Rong (ORCID: https://orcid.org/0000-0002-3960-1669)
- Susanne Mohr
- Michael Honer
- Ahmad Chaudhary (ORCID: https://orcid.org/0009-0007-0614-3335)
Institutions
- Roche (Switzerland) (CH)
- Emory Healthcare (US)
- Harvard University (US)
- Emory University (US)
- Emory University Hospital (US)
- ETH Zurich (CH)
- Wuhan University (CN)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1007/s00259-025-07564-w
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Emory University
- F. Hoffmann-La Roche
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- School of Medicine, Emory University