Nano-icilin–driven TRPM8 activation elicits immunogenic exosomes with antitumor effects
Activation of TRPM8 by icilin or cold can induce immunogenic exosomes, enhancing T cell infiltration, proinflammatory cytokines, and tumor suppression, offering a new strategy to boost immune responses against cancer.
Authors
- Salar Hemmati (ORCID: https://orcid.org/0000-0002-3431-8629)
- Ahmad Yari Khosroushahi (ORCID: https://orcid.org/0000-0003-3854-7311)
- Ghasem Noorkhajavi (ORCID: https://orcid.org/0000-0002-9309-686X)
- Mehdi Shahgolzari (ORCID: https://orcid.org/0000-0003-3246-8735)
- Steven Fiering (ORCID: https://orcid.org/0000-0003-0624-974X)
Institutions
- Dartmouth College (US)
- Tabriz University of Medical Sciences (IR)
Publication Details
- Journal
- Nanomedicine
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1080/17435889.2025.2583209
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00