Associations between obesity indices and cognitive function: Evidence from a middle‐aged observational and Mendelian randomisation study
This study demonstrates a negative association between BMI, WHR, TFM and cognitive function in middle-aged populations. Moreover, BMI, WHR and TFM appear to have a causal relationship with specific domain cognitive decline. Further multicentre, multiregional and large-scale studies are required to validate these findings.
Authors
- Jianbo Zhou (ORCID: https://orcid.org/0000-0003-2507-9192)
- Sisi Luan (ORCID: https://orcid.org/0000-0002-9144-9537)
- Wenke Cheng
- Pan Luo (ORCID: https://orcid.org/0000-0003-2593-1023)
- Jinyan Zhang (ORCID: https://orcid.org/0009-0001-2001-1773)
Institutions
- Beijing Tongren Hospital (CN)
- Bengbu Medical College (CN)
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Aviation General Hospital (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1111/dom.70221
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00