Reduced Wiskott-Aldrich syndrome protein expression in preeclampsia placenta impairs trophoblast syncytialization by modulating syncytin-2 via FAK/β-catenin pathway
We identified N-WASP as a key regulator of trophoblast syncytialization through the FAK/β-catenin signaling pathway, influencing syncytin-2 expression. The findings reveal a novel molecular mechanism underlying PE and suggest that N-WASP is a potential therapeutic target for PE.
Authors
- Yunpeng Ge (ORCID: https://orcid.org/0000-0002-3981-8972)
- Bai Zhang (ORCID: https://orcid.org/0000-0002-2234-4176)
- Chong Qiao (ORCID: https://orcid.org/0000-0002-4979-3545)
- Pin Cao
- Dan Wang (ORCID: https://orcid.org/0000-0002-5134-5418)
- Jiao Wang (ORCID: https://orcid.org/0000-0001-9875-5425)
- Shuo Zhang (ORCID: https://orcid.org/0000-0002-1572-6192)
- Hao Shen (ORCID: https://orcid.org/0000-0002-4235-4179)
Institutions
- Educational Department of Liaoning Province (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fcell.2025.1678878
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06