HMGB3 promotes brain metastasis of lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism
This study demonstrated HMGB3 as a key regulator of the brain metastasis of LUAD, orchestrating tumor cells' metabolic adaptation to the brain microenvironment through modulation of mitochondrial metabolism, thereby offering potential therapeutic targets for LUAD brain metastases.
Authors
- Changshuai Zhou (ORCID: https://orcid.org/0000-0003-3708-6146)
- Xiaojun Wu (ORCID: https://orcid.org/0000-0002-3809-6832)
- Yiqun Cao (ORCID: https://orcid.org/0000-0003-2905-0338)
- Sen Li (ORCID: https://orcid.org/0000-0001-5047-7518)
- Yuechao Yang
- Mingtao Feng
- Weiguo Hu (ORCID: https://orcid.org/0000-0002-7397-6800)
- Huanhuan Cui (ORCID: https://orcid.org/0000-0002-6190-6135)
- Lei Chen (ORCID: https://orcid.org/0000-0002-4726-7293)
- Hao Yan (ORCID: https://orcid.org/0000-0002-4322-7323)
- Yang Gao (ORCID: https://orcid.org/0000-0001-5796-8889)
- Xin Chen (ORCID: https://orcid.org/0000-0003-4019-552X)
- Liangdong Li (ORCID: https://orcid.org/0000-0002-0693-3018)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1002/cac2.70075
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00