Indocyanine Green Clearance Correlates With Biomarkers Reflecting Key Disease‐Driving Mechanisms in Advanced Chronic Liver Disease and Predicts Acute‐on‐Chronic Liver Failure and Death
ICG-R15 by PDD correlates with portal hypertension and systemic inflammation/circulatory dysfunction as key disease-driving mechanisms in ACLD. While showing insufficient discrimination for CSPH, ICG-R15 independently predicted ACLF/liver-related mortality in decompensated cirrhosis.
Authors
- Mattias Mandorfer (ORCID: https://orcid.org/0000-0003-2330-0017)
- David Bauer (ORCID: https://orcid.org/0000-0002-9363-8518)
- Michael Schwarz (ORCID: https://orcid.org/0000-0002-2587-1385)
- Tânia Carvalho (ORCID: https://orcid.org/0000-0002-9108-5489)
- Nina Dominik (ORCID: https://orcid.org/0009-0009-4615-915X)
- Paul Thöne (ORCID: https://orcid.org/0009-0001-1618-476X)
- Benedikt Simbrunner (ORCID: https://orcid.org/0000-0001-8181-9146)
- Lukas Hartl (ORCID: https://orcid.org/0000-0003-3398-6120)
- Matthias Pinter (ORCID: https://orcid.org/0000-0002-7260-532X)
- Michael Trauner (ORCID: https://orcid.org/0000-0002-1275-6425)
- Georg Semmler (ORCID: https://orcid.org/0000-0002-0411-166X)
- Thomas Reiberger (ORCID: https://orcid.org/0000-0002-4590-3583)
- Benedikt Silvester Hofer (ORCID: https://orcid.org/0000-0003-3403-3372)
- Albert Friedrich Stättermayer (ORCID: https://orcid.org/0000-0003-0737-4091)
- Mathias Jachs (ORCID: https://orcid.org/0000-0003-2871-4147)
- Lorenz Balcar (ORCID: https://orcid.org/0000-0002-6708-3061)
- Georg Kramer (ORCID: https://orcid.org/0009-0008-1736-3699)
- Christian Sebesta (ORCID: https://orcid.org/0009-0001-7504-8506)
Institutions
- Christian Doppler Laboratory for Thermoelectricity (AT)
- Unidade Hospitalar de Bragança (PT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1111/apt.70447
- Citations
- 2
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- Ludwig Boltzmann Gesellschaft