Glucocerebrosidase Target Engagement and Therapeutic Plasma and Cerebrospinal Fluid Levels After <scp>GT</scp> ‐02287 Administration in Healthy Volunteers
GT-02287 was safe and well-tolerated in healthy volunteers. Plasma and CSF levels were consistent with levels in rodents that modulate PD biology. © 2025 International Parkinson and Movement Disorder Society.
Authors
- Jonas Hannestad (ORCID: https://orcid.org/0000-0003-3772-4865)
- Terenzio Ignoni
- R. Pozzi (ORCID: https://orcid.org/0009-0003-3426-125X)
- Michele De Sciscio (ORCID: https://orcid.org/0000-0002-6159-2578)
- Sara Cano‐Crespo
- Joanne Taylor
- Manuela Bosetti (ORCID: https://orcid.org/0009-0003-1972-7701)
Institutions
- Rodin Therapeutics (United States) (US)
- Equipos Nucleares (Spain) (ES)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1002/mds.70111
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00