Metabolic factors influencing the efficacy of recombinant human growth hormone therapy in children with short stature
Insulin resistance, hyperinsulinemia, FT3, and HDL determine rhGH efficacy in short-statured children. Metabolic profiling optimizes rhGH therapy, and targeting insulin resistance may improve growth outcomes.
Authors
- Zhenhai Cui (ORCID: https://orcid.org/0000-0001-7619-9456)
- Kangli Xiao
- Kuanhong Luo
- Xueyu Zhong
- Geng Liu
- Huiqing Li
- Chen Yang (ORCID: https://orcid.org/0000-0001-6211-6218)
- Zhixin Wu (ORCID: https://orcid.org/0000-0003-0843-3882)
Institutions
- Union Hospital (HK)
- Diabetes Australia (AU)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fendo.2025.1691509
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China