Effectiveness Of 1% Metformin Gel And Xenograft On Bone Regeneration In Post Extraction Socket Through Osteoblast And Osteoclast Dynamics

Introduction: Basic components in engineering tissue is cells, scaffolding and signaling molecules. Bone graft is a bone reconstruction treatment that is a proponent in tissue engineering. Metformin is a diabetic medication also can be used as a signaling molecule in tissue engineering, regenerative agent in bone and soft tissue. Bone tissue is dynamic, with a decrease in osteoclast cell numbers and an increase in osteoblast cell numbers. The goal of this research is to determine the effect that metformin, with 1% formulation in bone regeneration in post-extraction sockets, which is determined through osteoblastic and osteoclastic dynamic. Method: Twenty-seven Cavia Cobaya had their incisivus extracted, then divided into negative control group with no treatment given, positive control group treated with xenograft, and Treatment group treated with xenograft plus 1% metformin gel. On day 7,14 and 28 rats were sacrificed, and histologically examined. Result: A decrease in osteoclast cells followed by an increase in osteoblast cell following 1% metformin gel and xenograft application Conclusion: Application of 1% Metformin Gel followed by Xenograft placement provide a major decrease in osteoclast cells and an increase in osteoblast cells.