Effect of Tualang Honey Concentration on the Morphology of Electrospun PVA Nanofibers for Wound Healing Application

Introduction: Tualang Honey (TH) is known for its antimicrobial and anti-inflammatory properties, making it a potential candidate for wound healing applications. Chronic wounds present a significant challenge in medical treatment due to their extended healing durations and elevated risk of infection. Materials and Methods: In this study, the potential of electrospun Polyvinyl Alcohol (PVA) nanofibers incorporated with Tualang Honey for wound healing was investigated. PVA nanofibers containing various concentrations of Tualang Honey (0%, 2%, 4%, and 6%) were prepared using the electrospinning method. The morphological and chemical characteristics of the synthesized nanofibers were evaluated. The water contact angle (WCA) of the nanofibers was also measured to assess hydrophilicity. Results: Scanning Electron Microscopy (SEM) revealed changes in fiber morphology with increasing honey concentrations, while Fourier Transform Infrared Spectroscopy (FTIR) confirmed the incorporation of honey within the nanofibers. WCA measurements indicated improved hydrophilicity with the addition of honey, particularly at higher concentrations. Optimal results were observed with 4% honey concentration, which demonstrated uniform fiber formation and enhanced hydrophilicity. Conclusion: The findings suggest that PVA/Tualang Honey nanofibers possess great potential for wound healing applications, merging the mechanical properties of PVA with the therapeutic benefits of honey.