HBsAg decline and clearance with peg-IFN therapy added to nucleos(t)ide analogues: an individual participant data meta-analysis of prospective trials (PROSPER)
Peg-IFN add-on results in HBsAg loss in 18% of patients with SOT HBsAg<1000 IU/mL, and in 38% if SOT HBsAg<100 IU/mL. Among patients with higher HBsAg levels, peg-IFN could be used to reduce HBsAg to below thresholds associated with response to novel compounds.
Authors
- Seng Gee Lim (ORCID: https://orcid.org/0000-0003-0994-4932)
- Lesley A. Patmore (ORCID: https://orcid.org/0000-0002-2911-2140)
- Marc Bourlière (ORCID: https://orcid.org/0000-0001-8976-9200)
- Qiankun Hu (ORCID: https://orcid.org/0000-0002-7024-7047)
- Bettina E. Hansen (ORCID: https://orcid.org/0000-0001-8307-3341)
- J.A. Carrión (ORCID: https://orcid.org/0000-0001-7191-6081)
- Harry L.A. Janssen (ORCID: https://orcid.org/0000-0003-2398-8392)
- Jordan J. Feld (ORCID: https://orcid.org/0000-0003-2640-2211)
- Fabien Zoulim (ORCID: https://orcid.org/0000-0002-2245-0083)
- Milan J. Sonneveld (ORCID: https://orcid.org/0000-0002-9253-563X)
- Scott Fung (ORCID: https://orcid.org/0000-0003-0501-8800)
- Teresa Broquetas (ORCID: https://orcid.org/0000-0002-5935-3076)
- Qing Xie (ORCID: https://orcid.org/0000-0002-2582-8803)
- Nathalie Ganne‐Carrié (ORCID: https://orcid.org/0000-0002-7351-5027)
- Willem Pieter Brouwer (ORCID: https://orcid.org/0000-0001-8713-1481)
- Edo J. Dongelmans (ORCID: https://orcid.org/0000-0003-2746-1643)
- Shaowen Jiang (ORCID: https://orcid.org/0009-0002-3277-4732)
- Fabrice Carrat (ORCID: https://orcid.org/0000-0002-8672-7918)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University Health Network (CA)
- Inserm (FR)
- National University of Singapore (SG)
- Universitat Pompeu Fabra (ES)
- Lyon College (US)
- University of Toronto (CA)
- Ruijin Hospital (CN)
- Toronto General Hospital (CA)
- Erasmus MC (NL)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Centre de Recherche des Cordeliers (FR)
- La Ligue Contre le Cancer (FR)
- Ontario Stroke Network (CA)
- Hospices Civils de Lyon (FR)
- Shanghai Public Health Clinical Center (CN)
- Hôpital Saint Joseph (FR)
- Hôpital Avicenne (FR)
- Hospital Del Mar (ES)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- National University Health System (SG)
- Hospital del Mar Research Institute (ES)
- Huashan Hospital (CN)
- Economic & Social Sciences, Health Systems & Medical Informatics (FR)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- Gut
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1136/gutjnl-2025-336251
- Citations
- 2
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- European Association for the Study of the Liver