Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach
Nutraceutical strategies that restore Trp metabolism or IPA serve as both a biomarker and a treatment for DR.
Authors
- Bruce R. Stevens
- Elizabeth M. Johnson (ORCID: https://orcid.org/0000-0003-3100-6969)
- Gavin Y. Oudit (ORCID: https://orcid.org/0000-0002-9154-9028)
- Regina Lamendella (ORCID: https://orcid.org/0000-0002-0952-1326)
- Borhane Eddine Chérif Ziani (ORCID: https://orcid.org/0000-0002-9650-5673)
- Mohit Bansal
- Ramon C. Sun (ORCID: https://orcid.org/0000-0002-3009-1850)
- Sarbodeep Paul
- Yvonne Adu-Agyeiwaah (ORCID: https://orcid.org/0000-0003-3899-7064)
- Jason L. Floyd (ORCID: https://orcid.org/0000-0002-7452-1680)
- Sergio Li Calzi (ORCID: https://orcid.org/0000-0001-8963-1519)
- Suresh K Verma (ORCID: https://orcid.org/0000-0002-0739-1302)
- Roshan Dutta (ORCID: https://orcid.org/0000-0001-8146-1041)
- Ram Prasad (ORCID: https://orcid.org/0000-0002-1931-5040)
- Michael E. Boulton (ORCID: https://orcid.org/0000-0002-0796-1766)
- Micheli S. Sielski (ORCID: https://orcid.org/0000-0002-6682-7954)
- Edgar L. Ready
- Craig W. Vander Kooi (ORCID: https://orcid.org/0000-0002-7463-3914)
- Justin Wright (ORCID: https://orcid.org/0000-0002-1132-8349)
- Robert F. Rosencrans (ORCID: https://orcid.org/0000-0002-6268-989X)
- Maria B. Grant (ORCID: https://orcid.org/0000-0002-6470-0255)
- Qiuhong Li
- Xiaoping Qi
- Rati Sharma
- Nicholas G Medawar
- Fadeela Sheini
Institutions
- University of Alabama at Birmingham (US)
- University of Florida (US)
- ID Genomics (United States) (US)
- Women and Children’s Health Research Institute (CA)
- Juniata College (US)
- Florida College (US)
Publication Details
- Journal
- Gut
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1136/gutjnl-2025-336180
- Citations
- 1
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Research to Prevent Blindness
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases