Targeting HMGB1 in endothelial cells reverses heme-induced SIRS after radiofrequency ablation of hepatic hemangioma
Collectively, we demonstrated that heme induces SIRS through the ROS/HMGB1/NLRP3 pathway-regulated endothelial cell pyroptosis in mice, and hemopexin, a heme scavenger, and glycyrrhizin, a HMGB1 inhibitor, may be the potential strategies for further study for SIRS following the RFA of hepatic hemangioma for the first time.
Authors
- Shaohong Wang (ORCID: https://orcid.org/0000-0001-5421-2971)
- Ruize Gao
- Yirui Hou (ORCID: https://orcid.org/0000-0003-3136-3392)
- Changyu Yao (ORCID: https://orcid.org/0000-0002-2762-7896)
- Shilun Wu
- Jun Gao (ORCID: https://orcid.org/0000-0003-3837-3956)
- Li Xu (ORCID: https://orcid.org/0000-0003-2878-302X)
- Wenbing Sun (ORCID: https://orcid.org/0000-0002-6492-3563)
- Ying Zhou (ORCID: https://orcid.org/0000-0003-1228-9932)
- Liuyang Yu
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking University People's Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1680433
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00