A Mild Reductant N‐Heterocyclic‐Carbene‐Ligated Borane for <i>N</i> ‐Formylation of Amines with CO <sub>2</sub> under Ambient Conditions
A convenient and efficient metal‐free protocol has been reported for formylation of various amines with carbon dioxide. This reaction can proceed under ambient conditions and show a broad substrate scope, encompassing primary amines, secondary amines, chiral amino acid esters, and bioactive molecules. Furthermore, this method offers several advantages, including the preservation of substrate chirality, ease of separation and purification, and the suitability of formic acid and formate salts as reactants in this reaction.
Authors
- Fengjian Chu (ORCID: https://orcid.org/0000-0002-3577-1919)
- Wangyu Li (ORCID: https://orcid.org/0000-0003-2436-053X)
- Hongru Feng (ORCID: https://orcid.org/0000-0002-1021-6775)
- Shiwen Zhou
- He Tang
- Yuanjiang Pan (ORCID: https://orcid.org/0000-0003-2900-2600)
Institutions
- Zhejiang University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1002/adsc.70079
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China