Association between serum interleukin 8 levels and cardiovascular events in patients with chronic kidney disease
In a large cohort of patients with moderate-to-advanced CKD, higher IL-8 levels were associated with a greater risk of MACEs in women (but not in men) and higher mortality in both sexes. Further research is needed to assess the potential of IL-8 as a cardiovascular risk biomarker, clarify the clinical significance of the sex difference observed here and determine whether targeting IL-8 could reduce cardiovascular risk in CKD.
Authors
- Christian Combe (ORCID: https://orcid.org/0000-0002-0360-573X)
- Solène M. Laville (ORCID: https://orcid.org/0000-0002-0214-5567)
- Sophie Liabeuf (ORCID: https://orcid.org/0000-0001-5384-9006)
- Youssef Bennis (ORCID: https://orcid.org/0000-0002-0186-4797)
- Maxime Pluquet (ORCID: https://orcid.org/0000-0003-4330-2925)
- Ziad A. Massy (ORCID: https://orcid.org/0000-0001-5771-5996)
- Nicolas Mansencal (ORCID: https://orcid.org/0000-0001-5500-1535)
- Natália Alencar de Pinho (ORCID: https://orcid.org/0000-0002-0438-6487)
- Saı̈d Kamel
Institutions
- Université de Bordeaux (FR)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- CHU Ambroise Paré (BE)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Bordeaux Population Health (FR)
- Hôpital Ambroise-Paré (FR)
- Association pour l'Utilisation du Rein Artificiel (FR)
- Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires (FR)
- Université de Picardie Jules Verne (FR)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1093/ckj/sfaf336
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00