Interpretive consistency of a qualitative 68Ga-PSMA PET framework for treatment response assessment in hepatocellular carcinoma: a head-to-head comparison with cross-sectional imaging
A qualitative PSMA PET framework for HCC treatment response assessment yields nearly perfect interpretive consistency, outperforming CT/MRI-based criteria in post-ICI settings. These findings provide the foundation to validate PSMA-based response against oncologic outcomes in future clinical trials, a critical step toward guiding patient management and accelerating therapeutic innovation in HCC.
Authors
- Nandakumar G. Patnam (ORCID: https://orcid.org/0000-0001-9606-7223)
- Aashna Karbhari (ORCID: https://orcid.org/0000-0003-2355-6717)
- Mark Jacobson
- Sovanlal Mukherjee (ORCID: https://orcid.org/0000-0002-8238-4794)
- Nguyen H. Tran (ORCID: https://orcid.org/0000-0002-6104-6489)
- Bradley J. Kemp (ORCID: https://orcid.org/0000-0002-2360-2368)
- Scott M. Thompson (ORCID: https://orcid.org/0000-0001-7853-3278)
- Ajit H. Goenka (ORCID: https://orcid.org/0000-0002-7804-2695)
- Kamaxi H. Trivedi (ORCID: https://orcid.org/0000-0001-8063-2750)
- Garima Suman (ORCID: https://orcid.org/0000-0002-4875-3170)
- Ajith Antony (ORCID: https://orcid.org/0009-0008-2265-8758)
Institutions
- Mayo Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Washington (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1007/s00259-025-07629-w
- Citations
- 3
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.97