Longitudinal study evaluating the role of physical activity in modifying Parkinson's disease progression

The role of physical activity in modifying Parkinson's disease progression is of interest. This longitudinal study followed 118 patients with idiopathic Parkinson's disease over 24 months to evaluate the impact of physical activity on disease progression. Participants were grouped based on physical activity levels sedentary, moderately active and highly active using standardized activity questionnaires. Disease severity was assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr staging. Patients with higher physical activity levels showed slower motor and functional decline compared to sedentary individuals. Thus, we show that regular physical activity may positively influence the trajectory of Parkinson's disease.