Dual CDK and MEK Inhibition potentiates CD8+ T cell-mediated antitumor immunity by inducing pyroptotic cell death in high-mutational head and neck cancer
Our findings indicate that the combination of AZD5438 and PD0325901 holds therapeutic potential for the treatment of HPV (-) HNSCC, particularly in tumors with a high mutational burden. By targeting complementary pathways, this combination may improve treatment outcomes in this aggressive cancer subtype.
Authors
- Aimee Payne (ORCID: https://orcid.org/0000-0001-9389-7918)
- Jianqiang Yang (ORCID: https://orcid.org/0000-0003-1857-4590)
- Fanghui Chen (ORCID: https://orcid.org/0000-0001-5571-8747)
- Fang Yang (ORCID: https://orcid.org/0000-0002-7092-2532)
- Nabil F. Saba (ORCID: https://orcid.org/0000-0003-4972-1477)
- Jin Xie (ORCID: https://orcid.org/0000-0002-8915-6233)
- Chunjuan Tang (ORCID: https://orcid.org/0000-0002-9521-4997)
- Lynn Zhang
- Nicole C. Schmitt (ORCID: https://orcid.org/0000-0002-0571-3531)
- Yong Teng (ORCID: https://orcid.org/0000-0002-1856-7289)
- David O. Popoola
- Yamin Li (ORCID: https://orcid.org/0000-0002-5535-1807)
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
- University of Georgia (US)
- SUNY Upstate Medical University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s13046-025-03557-7
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00