Spatial and functional dissection of cancer-associated fibroblasts-mediated immune modulation in H. pylori-associated gastric cancer
These findings reveal infection-associated stromal programs that shape the immune landscape in GC and highlight CAF-directed pathways as potential therapeutic targets in H. pylori-associated GC.
Authors
- Alvin H.K. Cheung (ORCID: https://orcid.org/0000-0002-3913-8117)
- Jingya Liu
- Yi Xu (ORCID: https://orcid.org/0000-0003-2720-0005)
- Shouyu Wang (ORCID: https://orcid.org/0000-0002-0466-1274)
- Yigan Zhang (ORCID: https://orcid.org/0000-0002-2633-1655)
- Canbin Fang (ORCID: https://orcid.org/0000-0001-7974-0447)
- Ka‐Fai To (ORCID: https://orcid.org/0000-0003-4919-3707)
- William Ka Kei Wu (ORCID: https://orcid.org/0000-0002-5662-5240)
- Elke Burgermeister (ORCID: https://orcid.org/0000-0002-4969-5697)
- Justin Chak Ting Cheung (ORCID: https://orcid.org/0000-0001-7586-7352)
- Bonan Chen (ORCID: https://orcid.org/0000-0002-2430-7934)
- Zhangding Wang (ORCID: https://orcid.org/0000-0002-3959-4542)
- Kam Tong Leung (ORCID: https://orcid.org/0000-0002-7695-2513)
- Wei Kang (ORCID: https://orcid.org/0000-0002-4651-677X)
- Xiaohong Zheng (ORCID: https://orcid.org/0000-0002-3027-1042)
- Man Tong (ORCID: https://orcid.org/0000-0001-5725-0391)
- Ruoxi Tian
- Jialin Wu (ORCID: https://orcid.org/0000-0002-5369-4371)
- Jun Qing Yu (ORCID: https://orcid.org/0000-0001-5008-2153)
- Yang Lyu
- Cheng Lu (ORCID: https://orcid.org/0000-0002-8577-4288)
- Fengbin Zhang (ORCID: https://orcid.org/0000-0003-4041-8770)
- Feng Xie
- Yujuan Dong (ORCID: https://orcid.org/0000-0003-0457-0337)
- Chi Chun Wong (ORCID: https://orcid.org/0000-0003-4520-2688)
- Hongzhen Tang (ORCID: https://orcid.org/0009-0004-7419-8483)
- Peiyao Yu
- Tiejun Feng
Institutions
- Hebei Medical University (CN)
- Guangzhou University of Chinese Medicine (CN)
- Hubei University of Medicine (CN)
- Harbin Medical University (CN)
- Chinese University of Hong Kong (HK)
- Harbin Institute of Technology (CN)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- HKUST Shenzhen Research Institute (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Taihe Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- University Medical Centre Mannheim (DE)
- Southern Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12943-025-02490-9
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39