Preoperative plasma ceramide profiling coupled with machine learning accurately predicts recurrence of hepatocellular carcinoma after resection
Preoperative plasma CER profiling, integrated with clinical parameters in a GBM framework, provides a highly accurate and interpretable strategy for predicting postoperative HCC recurrence, which paves the way for precise risk stratification and targeted management. This study provides insights that may enhance liver health and reduce disease burden in patients with HCC.
Authors
- Baoxiong Zhuang
- Jieyuan Li (ORCID: https://orcid.org/0000-0003-3666-9796)
- Leyi Liao
- Lei Yang (ORCID: https://orcid.org/0000-0001-6328-6518)
- Shushu Li (ORCID: https://orcid.org/0009-0002-4657-2728)
- Cuiting Liu (ORCID: https://orcid.org/0000-0002-6893-0787)
- Dongqing Cai (ORCID: https://orcid.org/0000-0002-6014-5362)
- Shanhua Tang
- Kai Wang (ORCID: https://orcid.org/0000-0001-5814-817X)
- Biao Wang (ORCID: https://orcid.org/0000-0001-7691-4368)
- Ping Chen (ORCID: https://orcid.org/0000-0002-9940-4528)
- Yiyi Li (ORCID: https://orcid.org/0000-0003-0684-7467)
- Xuming Mo
- Minghui Zeng (ORCID: https://orcid.org/0000-0002-6055-6495)
- Chuanjiang Li (ORCID: https://orcid.org/0000-0002-3583-2881)
- Jie Zhou (ORCID: https://orcid.org/0000-0003-0376-0622)
- Yuancan Xiao
- Haiqing 海庆 LIU 刘 (ORCID: https://orcid.org/0000-0001-5721-0728)
- Qingping Li (ORCID: https://orcid.org/0000-0002-7147-1243)
Institutions
- Nanfang Hospital (CN)
- First People's Hospital of Foshan (CN)
- Guangzhou Eighth People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1186/s12944-025-02749-6
- Citations
- 1
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Southern Medical University
- Nanfang Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province