Glycemic Responses to Graded Exercise Testing in Adolescents Using Automated Insulin Delivery Systems

This study evaluated the glycemic responses to a graded exercise test (GXT) performed by 24 adolescents with type 1 diabetes (T1D) using automated insulin delivery (AID) systems. Each participant partook in a GXT on a bicycle ergometer until volitional exhaustion. Plasma glucose and lactate levels were measured during the GXT, whereas sensor glucose was monitored in the hours thereafter. Plasma glucose levels were stable throughout the GXT (overall change of -0.26 mmol/L [-5 mg/dL], <i>P</i> = 0.593), with no hypoglycemic events. Sensor glucose levels also remained stable and within the recommended glucose target ranges after the GXT for the remaining day and night, with only a few episodes of mild hypoglycemia. This study highlights the glycemic safety of performing GXT for adolescents utilizing AID systems.