Hepatic activating transcription factor 3 protects against systemic inflammation by attenuating lipotoxicity
Our findings collectively indicate that hepatocyte ATF3 alleviates systemic inflammation by reducing hepatic lipotoxicity, a mechanism that may involve the activation of AMPKα. Targeting hepatic ATF3 represents a promising therapeutic strategy for systemic inflammation induced by hepatic lipotoxicity.
Authors
- Chencheng Hu
- Yanyong Xu
- Runzhi Yu
- Shuwei Hu (ORCID: https://orcid.org/0000-0001-9535-1556)
- Qian Yang (ORCID: https://orcid.org/0000-0002-3978-096X)
- Bing Meng
Institutions
- Handan College (CN)
- Shanghai Medical College of Fudan University (CN)
- Ministry of Education (KR)
Publication Details
- Journal
- Metabolism Open
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.metop.2025.100417
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00