Preparation and Preliminary Evaluation of a Novel <sup>68</sup> Ga-Labeled Linear Peptide PET Probe Targeting Nectin-4
[<sup>68</sup>Ga]Ga-NOTA-SP using a linear peptide as a vector shows favorable pharmacokinetics and specific targeting ability to Nectin-4, enabling rapid tumor mouse model imaging. It would be a promising PET/CT imaging probe for optimizing Nectin-4-related tumor diagnoses and therapy.
Authors
- Chao Mu
- Xin Cao (ORCID: https://orcid.org/0000-0003-3459-7207)
- Dong Li (ORCID: https://orcid.org/0000-0002-4538-9350)
- Min Chen (ORCID: https://orcid.org/0000-0002-4290-9330)
- Zheng Li (ORCID: https://orcid.org/0000-0002-5331-2417)
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Applied Physics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cancer Biotherapy and Radiopharmaceuticals
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1177/10849785251393840
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00