Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC
In a previous preclinical trial on human HNSCC xenografts, 18 genes were predictive for adding cetuximab to fractionated radiotherapy. Here, we apply the corresponding 18-gene classifier to two HNSCC patient cohorts treated with combined radiochemotherapy (without cetuximab). We show that the classifier is related to EGFR expression and stratifies patients for loco-regional control (LRC) in both cohorts.
Authors
- Claus Michael Rödel (ORCID: https://orcid.org/0009-0006-1777-2359)
- Mechthild Krause (ORCID: https://orcid.org/0000-0003-1776-9556)
- Stephanie E. Combs (ORCID: https://orcid.org/0000-0002-5233-1536)
- Claus Belka (ORCID: https://orcid.org/0000-0002-1287-7825)
- Fabian Lohaus (ORCID: https://orcid.org/0000-0003-4043-7066)
- Anca-Ligia Grosu (ORCID: https://orcid.org/0000-0003-2255-2255)
- Dominik Haim (ORCID: https://orcid.org/0000-0002-5299-3468)
- Maximilian Fleischmann
- Max Kemper
- Goda Kalinauskaitė (ORCID: https://orcid.org/0000-0003-3798-1546)
- Steffen Löck (ORCID: https://orcid.org/0000-0002-7017-3738)
- Kristin Gurtner (ORCID: https://orcid.org/0000-0003-2117-2760)
- Annett Linge (ORCID: https://orcid.org/0000-0001-9636-1721)
- Martin Stuschke (ORCID: https://orcid.org/0000-0001-6836-0940)
- Gustavo Baretton (ORCID: https://orcid.org/0000-0002-4051-6306)
- Jürgen Debus (ORCID: https://orcid.org/0000-0002-6411-4811)
- Michaël Baumann (ORCID: https://orcid.org/0000-0002-9340-974X)
- Simon Boeke (ORCID: https://orcid.org/0000-0002-3210-3368)
- Lydia Koi (ORCID: https://orcid.org/0009-0006-9187-7394)
- Inge Tinhofer
Institutions
- Goethe University Frankfurt (DE)
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- National Center for Tumor Diseases (DE)
- University Children's Hospital Tübingen (DE)
- OncoRay (DE)
- University Hospital Carl Gustav Carus (DE)
- University of Duisburg-Essen (DE)
- Technical University of Munich (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.ctro.2025.101067
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00