<i>HLA-C</i> *03:04:01 and <i>HLA-B</i> *15:18:01 but not <i>HLA-DQA1</i> *05 associated with anti- tumor necrosis factor antibody formation in Taiwanese inflammatory bowel disease patients
In Taiwanese IBD patients, <i>HLA-C</i>*03:04:01 and <i>HLA-B</i>*15:18:01 were significantly associated with ADA development to infliximab and adalimumab, respectively. <i>HLA-DQA1</i>*05 was not predictive, highlighting ethnic differences in genetic predisposition to immunogenicity.
Authors
- Meng‐Tzu Weng (ORCID: https://orcid.org/0000-0002-4143-6607)
- Chien‐Chih Tung (ORCID: https://orcid.org/0000-0002-5468-9064)
- Jau‐Min Wong (ORCID: https://orcid.org/0000-0002-8971-3001)
- Pei‐Lung Chen (ORCID: https://orcid.org/0000-0002-5640-3074)
- Shu-Chen Wei
- Chi‐Yuan Yao (ORCID: https://orcid.org/0000-0001-5052-9445)
- Wei‐Chen Lin (ORCID: https://orcid.org/0000-0002-8142-538X)
- Chunying Wang (ORCID: https://orcid.org/0000-0002-6554-1188)
- Sheng-Kai Lai (ORCID: https://orcid.org/0009-0001-7630-4997)
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3748/wjg.v31.i41.111745
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82