Accurate Single-Nanoparticle Sizing down to 3 nm with an Optofluidic Microcavity

Nanoparticles are ubiquitous, and methods that reveal insights into single-particle properties are highly desired to enable their advanced characterization. Techniques that achieve label-free single-nanoparticle detection often lack bandwidth or do not provide quantitative information. Here, we present a cavity-based dispersive sensing method that achieves a high bandwidth to capture all relevant time scales of translational diffusion and a sensitivity to detect and size single particles with diameters down to 3 nm. We develop an analytical model describing the autocorrelation function for particle diffusion in a standing-wave sensing geometry and propose a method to address the challenges posed by the transient nature of single-particle signals. With this, we achieve quantitative particle sizing with high precision and accuracy and provide an important tool to analyze single-particle diffusion.