Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is associated with inflammation and disease severity in pemphigus

This study found elevated levels of inflammatory cytokines (TWEAK, IL-6, TNF-α) and chemokines (CCL5, CXCL8) in the circulation of patients with PV, which correlated with disease severity. Additionally, localized immune dysregulation involving neutrophils, macrophages and T cells was seen in PV skin lesions. We highlight the involvement of TWEAK in enhancing chemokine expression and cell adhesion injury in PV, which suggests a promising therapeutic avenue targeting TWEAK and inflammatory cytokines in the management of PV.